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Contrave is often a combination in the drugs naltrexone and bupropion, which usually reflect a fresh trend of weight-loss drugs which are made up of several active ingredient, which might make them more efficient and safer. Combo-pilling is the newest fad or better yet the newest in the future under scrutiny and therefore it is just more publicly known although in the past, comb-pilling to lose weight has been around since the eighties. The biggest reason that using a combination of pills is now popular will be the fact that since right now there aren't any long term prescription weightloss pills that have been licensed by the FDA aside from orlistat. The truly disturbing part is always that doctors are prescribing these combinations of medications however some of the combinations happen to be rejected or have yet to be licensed by the FDA. Seizures can be a side effect with Contrave and really should not be taken in those with seizure disorders. The drug may also raise hypertension and heartbeat, and really should not be used in people with a history of cardiac event or stroke in the previous six months. Blood pressure and pulse should also be measured before starting the drug and throughout therapy with the drug. The FDA also warned that Contrave can raise blood pressure and heart rate and must not used in patients with uncontrolled high blood pressure levels, in addition to by you aren't heart-related and cerebrovascular (circulation system dysfunction impacting the mind) disease. Patients having a history of cardiac event or stroke in the earlier six months, life-threatening arrhythmias, or congestive heart failure were excluded from the clinical trials. Those taking Contrave really should have their heart-rate and pulse monitored regularly. 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